Evidence-based treatments for couples with unexplained infertility: a guideline

Overtreatment in couples with unexplained infertility.

STUDY QUESTION What is the percentage of overtreatment, i.e. fertility treatment started too early, in couples with unexplained infertility who were eligible for tailored expectant management? SUMMARY ANSWER Overtreatment occurred in 36% of couples with unexplained infertility who were eligible for an expectant management of at least 6 months. WHAT IS KNOWN ALREADY Prognostic models in repr...

Unexplained Infertility, the Controversial Matter in Management of Infertile Couples

30% of infertile couples worldwide are diagnosed with unexplained or idiopathic infertility and the problem is defined as the lack of an obvious cause for a couple's infertility and the females' inability to get pregnant after at least 12 cycles of unprotected intercourse or after six cycles in women above 35 years of age for whom all the standard evaluations are normal. The veracity of 'unexpl...

Pregnancy rate after endometrial injury in couples with unexplained infertility: A randomized clinical trial

BACKGROUND Unexplained infertility is still a challenging issue as to its causes, appropriate management and treatment. Evidence implicates early embryopathy or implantation failure as likely causes. OBJECTIVE This study aims to investigate the effect of local endometrial injury on pregnancy rate in selected unexplained infertile patients. MATERIALS AND METHODS This was a randomized clinica...

Unexplained Infertility

Endometriosis and infertility: epidemiology and evidence-based treatments.

Endometriosis is an estrogen-dependent disorder defined as the presence of endometrial tissue outside of the uterine cavity. A leading cause of infertility, endometriosis has a prevalence of 0.5-5% in fertile and 25-40% in infertile women. The optimal choice of management for endometriosis-associated infertility remains obscure. Removal or suppression of endometrial deposits by medical or surgi...